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IntroductionA high calcium-phosphate product is thought to increase the risk of soft tissue calcification in hypoparathyroidism, including cataracts. Based on small case series, cataracts in hypoparathyroidism typically develop in the posterior subcapsular region of the lens. However, the mechanism of cataract formation is still not well understood.Materials and methodsIn a large cohort of 1014 patients with ...

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ea0044p165 | Neuroendocrinology and pituitary | SFEBES2016

Olfactory neuroblastoma: a multi centre clinical and pathological review

Young Karen , Orban Nara , Clarke Peter , Sandison Ann , Gilkes Catherine , Alusi Ghassan , Korbonits Marta

Olfactory neuroblastoma (ONB) is a rare neuroendocrine tumour arising within the sino-nasal cavity. It occurs world wide, affecting both sexes, all ages and all races with no underlying predilection having yet been identified. ONB exhibits a range of phenotypes from indolent to very aggressive, and up to 5% cases are associated with ectopic hormone secretion. Despite current gold-standard treatment of surgical resection (either endoscopic or craniofacial resection) followed by...

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ea0081rc8.6 | Rapid Communications 8: Calcium and Bone | ECE2022

Health related quality of life in adults with hypoparathyroidism in an exploratory analysis of the phase 2 PaTH forward trial of TransCon PTH

Palermo Andrea , Vokes Tamara J , Khan Aliya , Rubin Mishaela , Schwarz Peter , Clarke Bart L , Eriksen Erik , Marcocci Claudio , Pagotto Uberto , Tsourdi Elena , Sikjaer Tanja , Brod Meryl , Mcleod Lori , Markova Denka , Noori Wahidullah , Eng Walter Frank , Shu Aimee , Smith Alden

Background: Patients with hypoparathyroidism experience significant physical and cognitive symptoms and reduced health-related quality of life (HRQoL). Conventional therapy for hypoparathyroidism does not fully alleviate diminished HRQoL. The Hypoparathyroidism Patient Experience Scales (HPES) were developed to assess disease-specific physical and cognitive symptoms as well as the impact of hypoparathyroidsm on HRQol. TransCon PTH, an investigational long-acting prodrug of par...

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ea0050p243 | Neoplasia, Cancer and Late Effects | SFEBES2017

Analysis of the diagnosis, treatment and genetics of 175 cases of phaeochromocytoma and paraganglioma in two ENETS Centres of Excellence

Stoenchev Kostadin , McDonald Basil , Dean Sophie , Canham Natalie , Palazzo Fausto , Banga Neal , Clarke Peter , Harcourt Jonathan , Baker Darryl , Todd Jeannie , Martin Niamh , Wernig Florian , Chahal Harvinder , Sam Amir , Hatfield Emma , Dhillo Waljit , Meeran Karim , Grossman Ashley , Toumpanakis Christos , Caplin Martyn , Tan Tricia , Khoo Bernard

Background: Phaeochromocytomas (PCC) and paragangliomas (PGL) are tumours derived from neural crest cells within the adrenal medulla or extra-adrenal ganglia, respectively. Over 20 known genes are implicated in at least 30% of cases. Experience with these tumours in individual centres is limited due to their rarity.Objective: To describe the demographics, genetics, treatment and progression-free survival (PFS) in ...

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ea0050p243 | Neoplasia, Cancer and Late Effects | SFEBES2017

Analysis of the diagnosis, treatment and genetics of 175 cases of phaeochromocytoma and paraganglioma in two ENETS Centres of Excellence

Stoenchev Kostadin , McDonald Basil , Dean Sophie , Canham Natalie , Palazzo Fausto , Banga Neal , Clarke Peter , Harcourt Jonathan , Baker Darryl , Todd Jeannie , Martin Niamh , Wernig Florian , Chahal Harvinder , Sam Amir , Hatfield Emma , Dhillo Waljit , Meeran Karim , Grossman Ashley , Toumpanakis Christos , Caplin Martyn , Tan Tricia , Khoo Bernard

Background: Phaeochromocytomas (PCC) and paragangliomas (PGL) are tumours derived from neural crest cells within the adrenal medulla or extra-adrenal ganglia, respectively. Over 20 known genes are implicated in at least 30% of cases. Experience with these tumours in individual centres is limited due to their rarity.Objective: To describe the demographics, genetics, treatment and progression-free survival (PFS) in ...

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Endocrine Abstracts

Non-nuclear cataracts in hypoparathyroidism are associated with biochemical control of the disease

Olfactory neuroblastoma: a multi centre clinical and pathological review

Health related quality of life in adults with hypoparathyroidism in an exploratory analysis of the phase 2 PaTH forward trial of TransCon PTH

Analysis of the diagnosis, treatment and genetics of 175 cases of phaeochromocytoma and paraganglioma in two ENETS Centres of Excellence

Analysis of the diagnosis, treatment and genetics of 175 cases of phaeochromocytoma and paraganglioma in two ENETS Centres of Excellence

BiosciAbstracts